Enhancing reuse of structured eligibility criteria and supporting their relaxation

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Enhancing reuse of structured eligibility criteria and supporting their relaxation

Patient recruitment is one of the most important barriers to successful completion of clinical trials and thus to obtaining evidence about new methods for prevention, diagnostics and treatment. The reason is that recruitment is effort consuming. It requires the identification of candidate patients for the trial (the population under study), and verifying for each patient whether the eligibility...

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Epilepsy surgery has benefited from major advances during the last 20 years, thanks to the development of neuroimaging and long-term video-electroencephalographic (EEG) monitoring. However, it remains the case that only a small minority of potential epilepsy surgery candidates will have access to a comprehensive presurgical evaluation. Furthermore, this subset of patients are operated on after ...

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Patterns of Clinical Trial Eligibility Criteria

Medical research would benefit from automatic methods that support eligibility evaluation for patient enrollment in clinical trials and design of eligibility criteria. In this study we addressed the problem of formalizing eligibility criteria. By analyzing a large set of breast cancer clinical trials we derived a set of patterns, that capture typical structure of conditions, pertaining to synta...

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ژورنال

عنوان ژورنال: Journal of Biomedical Informatics

سال: 2015

ISSN: 1532-0464

DOI: 10.1016/j.jbi.2015.05.005